This should give you a 24-numbers encrypted serial number. You must then decrypt it (the "SoftKey Revealer" freeware for Windows has a decryption tool, you can also run it using wine on Linux and possibly Mac OS).
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Another way to decrypt the serial number, as opposed to downloading freeware tainted by evil payloads (at least one download site for "Softkey Revealer" has taint) is to run a simple JavaScript function (copied from elsewhere, but tested and works):
If you purchased Adobe Student & Teacher edition product, you may have received a serial number or a redemption code. See Serial numbers, redemption codes, and product codes Student & Teacher editions.
We suppose that you want to move Adobe Acrobat DC to the new computer but puzzled about how to transfer Adobe product license to another computer without installation disks, CD or serial number. This tutorial will show you how to transfer Adobe Acrobat DC from one computer to another and find serial number to activate the Acrobat DC application on the new computer.
If you purchased the Adobe Acrobat from Adobe website, you can find it online by accessing your Adobe ID account and sign in with your Adobe ID and password. Select My Products and Services. Click the arrow next to Adobe Acrobat DC to view the serial number.
Note: If you cannot see it listed there, you might be able to retrieve it from the old system using Product Key Finder. See how to find serial number for Adobe Acrobat on computer for your reference.
There are currently two different procedures of electron microscopy for microcircuital connectome, SBSEM (Helmstaedter et al., 2011), and SSTEM: serial section transmission electron microscopy (Anderson et al., 2011). Because membrane-to-membrane apposition without any synaptic contact may occur from place to place in neuropiles, direct visualization of chemical synapses and gap junctions is required for determining all synaptic connections (Anderson et al., 2011). In this respect, as compared to SBSEM, SSTEM is uniquely capable of identifying gap junctions with the aid of section tilting for observation angle adjustment. Furthermore, to determine whole retinal microcircuits, we need complete taxonomy of retinal neurons. Classification of all bipolar cells is one of the important steps to analyze the core part of retinal microcircuits.
In the first half of the results section, we validate the classification of bipolar cell types based on the distribution of synaptic ribbons in axon terminals and morphological parameters, including stratification level, arbor area, and arbor thickness. Wässle et al. (2009) suggested that type 5 cells might be divided into two groups mainly based on the coverage factor. By contrast, Greene et al. (2016) insisted that type 5 cells should be divided into three groups based on the detailed morphology of the axon terminal arbors and the coverage factor. However, morphological differences among the 5i, 5o, and 5t types are very subtle. Therefore, further characterization of type 5 cells at the level of synaptic contacts will contribute to eliminating ambiguity. Pang et al. (2004, 2010) suggested two distinct groups of RB cells: one (RB1) with a deeper axon terminal and less chloride channels than the other (RB2). We classified RB cells by inspecting the morphological counterparts of their physiological specifications. In particular, we sought to determine whether RB1 cells make membrane-to-membrane contacts with ganglion cell somas, as depicted by Cajal (1893) at the light microscopic level. Once determined, we investigated the possible existence of synaptic structures. Using cluster analysis, we assessed whether these two groups of RB cells are truly different or two variants of a single cell type.
Della Santina et al. (2016) identified a new type of neuron that they named a glutamatergic monopolar interneuron (GluMI). GluMI cells make glutamatergic ribbon synapses in the IPL. Electrophysiologically, this cell shows center-OFF responsiveness; morphologically, it has an axon but no dendrites. Using single-cell transcriptomics, Shekhar et al. (2016) revealed 15 types of bipolar cells, one of which has molecular markers of a bipolar cell but morphological characteristics of an amacrine cell. Because it has several pan-bipolar cell markers, the authors defined it as a type of bipolar cell and named it a BC1B cell. Based on its unique morphology, the BC1B cell is thought to correspond to the GluMI cell. In the same sampling area of the mouse retina we examined for the previous studies, we have now reconstructed three more cells similar to type GluMI or BC1B cells. Here, this novel type will be referred to as T1b, and cells previously defined as T1 will be referred to as T1a.
Although only one RB cell type is included on the list of bipolar cell types by Shekhar et al. (2016) and Pang et al. (2004) once described two distinct groups of RB cells: RB1 and RB2. Initially, we found two groups of RB cells. The axon terminals of RB cells in one group reached the GCL and had direct contact with somas of nearby ganglion or displaced amacrine cells. Those in the other group were slightly too short to reach the GCL and had no direct contact with any somas. Of 18 reconstructed RB cells, 11 cells belonged to RB1 and 7 cells to RB2.
Cluster analysis of eight types of ON bipolar cells and a reexamination of type 5a, 5b, and 5c cells. (A) The scatter plot shows thickness of an axon arbor vs. the distance between the axonal tip and the ganglion cell layer. (B) The scatter plot shows the top-view area of an axon arbor vs. the number of synaptic ribbons. (C) A dendrogram of cluster analysis (Ward's method) of 19 ON bipolar cells using the four variables plotted in (A,B). Two groups of cells (types 5b and 5c) are intermingled, but other cells are separated into six distinct clusters (types 5a, 5d, 6, 7, 8, and 9). (D) Side-view profiles of axon terminal arbors of type 5a, 5b, and 5c cells. (E) The vertical distribution of the number of synaptic ribbons per μm along the axon. (F) A dendrogram of cluster analysis (Ward's method) of 10 type 5 bipolar cells, using the distribution patterns of synaptic ribbons in (E).
Groupings of RB cells. (A) The depth (IPL axon length) of RB cells as measured by the distance from the INL-IPL border to the axon terminal. (B) The electron micrograph of a ribbon synapse (arrowhead and arrow) from a RB cell axon terminal to an amacrine cell (possibly type A17), and a conventional synapse (arrow) reciprocally directed from an amacrine cell to the RB cell axon terminal. (C) The electron micrograph of a ribbon synapse (arrowhead and arrow) from the RB cell axon terminal to an AII amacrine cell (AII-AC), and a conventional synapse (arrow) laterally directed from another amacrine cell to the RB cell. (D) The total number of amacrine cell synapses directed to RB cells. (E) The percentage of ribbon synapses with reciprocal feedback from immediate amacrine cell dendrites. (F) A scatter plot of the two variables in (D,E) which shows significant differences among the three RB cell subtypes. (G) Clustering of the 18 RB cells using the two variables in (F). (H) The total number of amacrine cell synapses directed to RB cells. (I) The percentage of ribbon synapses with reciprocal feedback from immediate amacrine cell dendrites. **p
Electron micrographs of synaptic contacts (arrows) between bipolar cells of particular types (TNo.), AII amacrine cells (AII-cell number), and ganglion cells (GC-cell number) in stratum 1 (S1) or 2 (S2) of the IPL. Arrowhead: synaptic ribbon. (A) AII-4 has an output synapse to the dendrite of GC-61 in S1. (B) Both AII-5 and T2 cells have output synapses to the dendrites of GC-31 in S1. The T2 cell also has a ribbon synapse to the AII-5 cell. (C) The T2 cell has an input synapse from an AII amacrine cell. (D) The T4 cell has an input synapse from an AII amacrine cell, as well as a ribbon synapse to another amacrine cell. (E) Both AII-2 and T3b cells have output synapses to the dendrites of GC-40 in S2. (F) Gap junctions (pairs of arrows) between AII-3 and T5a cells. The T5a cell also has a ribbon synapse to a ganglion cell. (G) The magnified gap junction (asterisk of F) shows a striped pattern of three black lines with two intervening white lines. This gap junctional area is coated by fluffy subsurface material with spaces of different sizes on both sides in the cytoplasm. The density profile along the line perpendicular to the cell membranes is the average across the area between the two dotted lines.
Type-dependent weighted outputs to bipolar cells from AII amacrine cells (AII-ACs). (A-1) The mean number of conventional synapses for output to different types of OFF bipolar cells, other amacrine cells, and ganglion cells per AII-AC (n = 3). (A-2) A pie chart showing the proportion of synapses to different types of bipolar cells. (B-1) The mean number of gap junctions with different types of bipolar cells and other AII-ACs per AII-AC (n = 3). (B-2) A pie chart showing the proportion of gap junctions with different types of bipolar cells. (B-3) A pie chart showing the proportion of gap-junction area with different types of bipolar cells. (C) The number of chemical synapses of AII-ACs and OFF bipolar cells per AII-AC. (D) The number of gap junctions of AII-ACs and ON bipolar cells per AII-AC. (E) The total area of gap junctions of AII-ACs and ON bipolar cells per AII-AC. 2ff7e9595c
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